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Best Southwest American Restaurants in Medical Center

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94 restaurants available nearby

A photo of Clementine restaurant
4.8
Exceptional(476)
Price: Very Expensive
• Mexican • North Central
Booked 16 times today
At Clementine, we’re serving seasonal, innovative eats in a modern & lively atmosphere. Our team, led by John (2023 James Beard nominee for Best Chef: Texas) and Elise Russ, draws inspiration from diverse global flavors. Our ever-evolving menu guarantees fresh and exciting options, while our dishes like the White Mushroom Salad, Ricotta Cavatelli and Clementine Crunch Bar remain cherished favorites. Our beverage menu is small but mighty, carefully curated to include only the most delicious wines & beers from our absolute favorite producers expertly selected to elevate your dining experience. Want your own bottle? Our corkage fee is $35 per 750ml.Our Dining Room provides comfortable indoor seating, while the Kitchen Bar boasts an exciting vantage point overlooking our open kitchen, allowing you to witness the creation of each dish. For a change of scenery, our covered patio, is perfect for al fresco dining, complete with heaters and blankets to keep you cozy on those cool nights.
A photo of Alamo Biscuit Company & Panaderia restaurant
4.2
Awesome(7)
Price: Moderate
• Mexican • Northwest
Booked 1 time today
Alamo Biscuit Company & Panaderia, located in the Northwest of San Antonio, is a beacon of American cuisine with a delightful twist. Patrons rave about the "delicious and HUGE" meals, like the smoked brisket Benedict and the egg, cheese, and brisket biscuit, which are a testament to the restaurant's commitment to quality and generosity in portions. The ambiance, described as "inviting," complements the expertly crafted dishes that blend traditional American flavors with a Tex-Mex flair, creating a unique dining experience. Visitors consistently highlight the "excellent service" and the atmosphere that makes every dining experience memorable. Whether it's for the "light and fluffy pancakes" or the "homemade buttermilk flavor of biscuits," Alamo Biscuit Company & Panaderia is a must-visit for anyone seeking authentic and innovative American fare.
A photo of 54th Street Restaurant & Drafthouse - The Colonnade restaurant
Price: Moderate
• Mexican • Medical Center
54th Street was founded in Kansas City, MO by Thomas E. Norsworthy in 1989. He envisioned a place that would accommodate a consistently crowded dining room as well as a lively bar crowd, while offering the quality food and drinks that exceed national chain competitors. At 54th Street, we believe that great food starts with fresh produce, high quality meats and ingredients and meals prepared from scratch. With our amazing range of scratch prepared menu items, we truly have something for everyone. The Five-Four promise is to forever uphold our tradition of serving generous portions of housemade food and drink at an honest price. 54th Street welcomes you for all occasions. Drop in for Happy Hour with friends, celebrate a special occasion, enjoy a family night out or fly solo! Ultimately, it’s your time. Join us, experience 54 and share the 54 experience with others.
A photo of Dave & Buster's - San Antonio (Balcones Heights) restaurant
4.6
Exceptional(102)
Price: Moderate
• Mexican • Medical Center
Booked 5 times today
Each Dave & Buster’s has more state-of-the-art games than ever, more mouth-watering menu items and the most innovative drinks anywhere. From wings to steaks, we’ve got whatever suits your appetite and our premium bar assures we’re stocked to satisfy! Plus, you can watch your game on one of our massive HDTVs with epic stadium sound.
A photo of Tu Asador - Castle Hills restaurant
4.8
Exceptional(134)
Price: Expensive
• Mexican • North Central
Booked 6 times today
Experience the vibrant heart of Mexico at Tu Asador - Castle Hills, where the essence of a Mexican Steakhouse comes alive. This celebrated steakhouse in North Central, Castle Hills, offers a unique gastronomic journey through Northern Mexico's rich culinary traditions, providing an authentic and delicious experience that goes beyond the ordinary. Guests rave about the "absolutely delicious" meals, such as the 1.5lb sirloin that perfectly feeds a family of three, and the ambiance that makes everyone feel like part of the Tu Asador family. The steakhouse has garnered glowing reviews for its exceptional service and atmosphere, making it a must-visit for steak enthusiasts. One reviewer exclaims it's one of the "top 3 steak places I've ever been to," highlighting the quality and authenticity that Tu Asador proudly serves up. Join in for a meal where every dish promises an unforgettable experience.
A photo of Red Lobster - San Antonio - NW Loop 410 restaurant
4.4
Awesome(15)
Price: Moderate
• Mexican • North San Antonio
Booked 2 times today
Elevate your day at Red Lobster, where fun meets fancy and every meal is a celebration. Whether you’re marking a special occasion or treating yourself or your crew, Red Lobster is the perfect place to enjoy all your seafood favorites. Dive into our signature shrimp, wild caught lobster and crab, and more. Plus, a variety of fish and popular non-seafood items like our Cajun Chicken Linguini Alfredo. Looking for a showstopper? Create Your Own Ultimate Feast or select a Live Maine Lobster straight from the tank. Or explore our Daily Deals with a different special available each weekday at a price you’ll love. Toast the day with Signature Cocktails including Lobster Punch and Main Deck Margarita Flights to make any moment feel festive. You won’t want to miss our newest menu items or special promotions like Lobsterfest and Crabfest. Reserve online today. Group Dining, To Go, or Catering options. For parties of 11+, please call.
A photo of Rock & Brews - San Antonio restaurant
4.3
Awesome(12)
Price: Moderate
• Mexican • North Central
Booked 10 times today
At Rock & Brews in North Central San Antonio, comfort food is elevated to an art form, delighting diners with its authentic American-inspired menu. Their dishes, crafted from scratch using locally sourced ingredients, promise a taste that's both genuine and innovative. The Gastro Pub burger, praised for its succulent combination of bacon, fried egg, and Swiss cheese, and the Nashville Hot Chicken Salad are particularly standout offerings. Patrons rave about the quality and flavor, with one noting, "the food was amazing." This unique blend of top-notch comfort food, an electric atmosphere, and exceptional service makes Rock & Brews a must-visit for anyone seeking a memorable dining experience in San Antonio.
A photo of Kona Grill - North Star restaurant
4.2
Awesome(580)
Price: Moderate
• Mexican • North San Antonio
Booked 7 times today
Kona Grill at North Star Mall in North San Antonio is an exemplary destination for authentic American cuisine, combining classic grill favorites with a unique twist. This restaurant stands out for its "global menu of contemporary American favorites, award-winning sushi, and specialty craft cocktails in a polished, casual atmosphere" that patrons adore. The quality of their steak is often praised as "Absolutely the best steak in Texas!" along with their exceptional service, making it a go-to spot for both locals and visitors. Reviewers consistently highlight the staff's attentiveness and the vibrant atmosphere, making every dining experience memorable. Whether it's for a hearty brunch, a delightful dinner, or a lively happy hour, Kona Grill at North Star offers a perfect blend of quality, service, and American cuisine flair.
A photo of Pinstack - San Antonio - Park North restaurant
3.8
Excellent(25)
Price: Moderate
• Mexican • Victoria
Booked 4 times today
Pinstack in Park North, San Antonio, is a vibrant cocktail bar and entertainment hub that truly stands out. With an extensive list of craft cocktails, 24 draft beers, and 12 keg wines, it caters to all tastes, ensuring a premium bar experience. Patrons rave about the atmosphere and the quality of drinks, with one visitor exclaiming, "The Paloma Pop mocktail was perfect for someone that doesn't really like sweet drinks!" The dedication to providing a diverse and quality drink selection makes Pinstack a top destination for cocktail enthusiasts looking for an upscale, enjoyable night out in Victoria, San Antonio. Whether you're in for the bowling or the bumper cars, the cocktail experience here is not to be missed.
A photo of Chart House Restaurant - Tower of the Americas restaurant
4.5
Awesome(16479)
Price: Moderate
• Mexican • Downtown
Booked 214 times today
Dine in the heart of Downtown San Antonio at Chart House Restaurant, a haven of American cuisine that promises more than just a meal. Celebrated for both its culinary prowess and enchanting views, Chart House offers an array of finely-crafted American dishes, from fresh fish specialties to the sumptuous slow-roasted prime rib. Guests rave about the "delicious food and great service," with highlights including the "best key lime pie ever" and an original Hot Chocolate Lava Cake that perfectly concludes a memorable dining experience. Whether it's the stunning city vistas or the "exceptional service," Chart House provides a dining experience that consistently delights and surprises, making it a must-visit for locals and tourists alike.
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you
From verified diners like you
  • Marta
    San Antonio •1 review
    5.0
    Dined today
    We opened the meal with a lime-forward, homemade guacamole topped with pico de gallo. It was addicting and worth every penny. It comes with a red chipotle, salsa verde with a bit more heat, and the most ethereal tortilla chips we've ever eaten. The Elotes, a quartered corn cob topped with a masa crunch and queso fresco chamoy, is every bit as good as it sounds. The reposado flight featured Wild Common, Agave de Cortes, and Carabuena and is served with palate-cleansing orange and jicama sprinkled with sal de chapulines. Aguachile Verde, a vibrant, beautifully presented ceviche of red snapper, cucumber, and Serrano chilies served in a mildly spicy tomatillo sauce. I craved more acidity, however I can also acknowledge that, coming off of the guacamole, my tastebuds might have needed a reset. The Chuleta Asada, with Berkshire pork, snuggled into a salsa de queso, combined with the rice made for an exceptional bite. Caramelos de Carnitas was served on a wheat tortilla that was flaky and the carnitas were seasoned like their Abuela taught them how to do it. Flauta de Papas came presented stunningly and were promptly dispatched by my daughter. The Chile Rellenos’ exterior crust was so expertly fried that it retained its crunch until the last bite. When you cut into it, the queso Oaxaca oozed out so beautifully. The Tres Leches, with Chef Tavel's signature salted cream, coconut, and Jamaica sauce was the favorite of the night. Chocoflan isn't the classic cake and flan dessert but an actual flan that sent my eyes rolling to the back of my head in ecstasy. The apple sorbete was topped with thick, homemade chamoy, and sprinkled with Tajín. I highly recommend Mezquite!
    More info
    MezquitePrice: Moderate• Northern Mexican• Downtown
    4.5
  • Shankar
    Calgary / Southern Alberta •2 reviews
    4.0
    Dined 3 days ago
    Good food and service. Really a cool spot for dinner
    More info
    Domingo RestaurantePrice: Expensive• Mexican / Southwestern• Downtown
    4.4
  • Richard
    South Carolina •5 reviews
    5.0
    Dined 6 days ago
    Great experience and fantastic foods. Thanks to Gilbert, our server.
    More info
    ÁcenarPrice: Moderate• Contemporary Mexican• Downtown
    4.5
  • Jacob
    Austin •3 reviews
    5.0
    Dined on 14 Nov 2024
    The food is surprisingly good, the flavor is always there even if the sauces are sometimes a little loose. Everything that everyone I know has ordered has been delicious! Definitely some of the best in town! Can’t wait to try the margaritas here!
    More info
    Las Guitarras RestaurantPrice: Moderate• Mexican• Boerne
    4.8
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