Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. San Diego

Best Southwest American Restaurants in Little Italy

Price
Regions
Areas
Top Rated
Dining Options
Seating Options
Award-winning
Accessibility

168 restaurants available nearby

A photo of Herb & Wood restaurant
4.7
Exceptional(6595)
Price: Expensive
• Mexican • Little Italy
Booked 107 times today
Herb & Wood in San Diego's vibrant Little Italy is a shining example of exquisite American cuisine. Celebrated Chef Brian Malarkey crafts a menu that elevates rustic, wood-fired dishes, blending Mediterranean flair with California's commitment to seasonality and sustainability. Diners rave about the "incredible dinner" experience, showcasing "amazing, flavorful food" and "outstanding service." The ambiance is described as "beautiful" and "welcoming," making every visit memorable. Signature dishes like the pork belly and filet mignon are praised for their exceptional taste. Whether you're celebrating a special occasion or enjoying a night out, Herb & Wood promises a "truly memorable culinary experience."
A photo of Ironside Fish & Oyster restaurant
4.6
Exceptional(4642)
Price: Moderate
• Mexican • Little Italy
Booked 86 times today
Ironside Fish & Oyster in San Diego's Little Italy is a quintessential hotspot for authentic American cuisine, seamlessly blending traditional and contemporary flavors. This gem pays homage to its roots in the fishing industry with a mouthwatering menu that features renowned dishes such as the lobster roll and clam chowder, praised for being “chock full of clams.” The vibrant atmosphere and top-notch service are frequently highlighted in reviews, with one diner noting the “excellent experience, food, and ambience.” With a stellar raw bar and an enticing happy hour, Ironside promises a “delightful experience” that diners find irresistible.
A photo of Kettner Exchange restaurant
4.7
Exceptional(1430)
Price: Expensive
• Mexican • Little Italy
Booked 65 times today
Kettner Exchange in Little Italy, San Diego, offers an exceptional Asian fusion experience that is both inventive and authentic. Executive Chef Brian Redzikowski’s creations have earned the restaurant a coveted spot on the Michelin Guide's Bib Gourmand list since 2019, showcasing high-quality meals at accessible prices. Diners rave about the "spicy garlic noodles" and "juicy cheeseburger special," underscoring the delightful fusion of flavors. The rooftop patio with stunning harbor views enhances the dining ambiance, making it perfect for any occasion. Guests frequently praise the "stellar service" and "amazing cocktails," solidifying Kettner Exchange as a must-visit destination for Asian cuisine enthusiasts.
A photo of King & Queen Cantina - San Diego restaurant
4.3
Awesome(1199)
Price: Moderate
• Mexican • Little Italy
Booked 18 times today
King & Queen Cantina in San Diego's vibrant Little Italy neighborhood is a must-visit for steak enthusiasts. While the restaurant is renowned for its eclectic Latin-Asian fusion, the steak dishes here are a true delight. Diners rave about the "perfectly cooked and seasoned" steaks, which showcase the restaurant's commitment to quality and authenticity. The lively atmosphere complements the exquisite flavors, making each visit a memorable experience. Whether you're enjoying a weekday dinner or a special occasion, the steak at King & Queen Cantina promises to elevate your dining experience with its rich, mouthwatering flavors and impeccable service.
A photo of Craft & Commerce restaurant
4.4
Awesome(1097)
Price: Expensive
• Mexican • Little Italy
Booked 37 times today
Craft & Commerce in Little Italy, San Diego, is celebrated for its exceptional Burgers that stand out in quality and authenticity. Diners rave about the "filling and flavorful" C&C Burger, which comes perfectly paired with fries and a delectable sauce. The burger is a star on their diverse menu, often praised for its ability to satisfy even the most discerning burger enthusiasts. With an upbeat atmosphere and a team that provides top-tier service, Craft & Commerce is a must-visit for burger lovers seeking a memorable dining experience. This spot truly embodies the spirit of great Burgers cuisine, making it a local favorite.
A photo of Crudo Ceviche & Oyster Bar restaurant
4.7
Exceptional(195)
Price: Moderate
• Mexican • Little Italy
Booked 17 times today
Crudo Ceviche & Oyster Bar in Little Italy, San Diego, offers an exceptional seafood dining experience that transports your taste buds straight to the vibrant coasts of Baja. Revered for its "excellent fresh fish" and "super fresh oysters," this culinary gem crafts each dish with quality ingredients and meticulous attention to detail. Diners rave about the "creative crudo, ceviche, and aguachile," each plate a testament to the restaurant’s dedication to authenticity and flavor. The unique tostadas are described as "a work of art," adding a visual feast to the already irresistible flavors. Crudo promises a seafood adventure that is "worth several visits."
A photo of Coco Maya restaurant
4.5
Awesome(394)
Price: Expensive
• Mexican • Little Italy
Booked 13 times today
Coco Maya in Little Italy, San Diego, is a vibrant cocktail bar that elevates your dining experience with "excellent drinks and ambience." Renowned for its diverse mezcal and tequila selection, this bar seamlessly blends tropical and rum-based cocktails, a hallmark that traces back to its roots at Miss B's Coconut Club. Guests rave about the "perfectly crafted espresso martini," which stands out among their expertly curated beverages. The lively rooftop setting, often accompanied by a DJ, adds a fun and energetic vibe that enhances the entire experience. If you're seeking a memorable cocktail adventure, Coco Maya promises to deliver!
A photo of Petrini's restaurant
4.5
Awesome(441)
Price: Moderate
• Mexican • Little Italy
Booked 8 times today
Petrini's in San Diego's vibrant Little Italy effortlessly brings authentic American cuisine to life with their exceptional dishes. While known for its Italian roots, the restaurant's dedication to quality and authenticity shines through its American offerings. Diners rave about the "excellent food," with dishes that are "just like homemade," ensuring a genuine American experience. Patrons are drawn not only for the delightful meals but also for the "great atmosphere" and "superb service," making it a beloved neighborhood gem. Whether you’re stopping by for brunch, lunch, or dinner, Petrini's promises a memorable American dining experience that keeps guests coming back.
A photo of Fisher's restaurant
4.1
Excellent(137)
Price: Expensive
• Mexican • Little Italy
Booked 1 time today
Fisher's in San Diego's vibrant Little Italy offers a seafood dining experience that's both authentic and exquisite. Renowned for its “unique and very tasty” dishes, Fisher's ensures every bite is a testament to the freshness of its offerings. The Seafood Rice, bursting with perfectly cooked varieties, and the Sea Bass with its “wonderful crispy crust” are standout dishes that have diners raving. Guests have lauded Fisher's for its “excellent service and food,” describing the seafood as “fresh, savory, tasty, and well-prepared.” With a legacy rooted in Mexico City flavors, Fisher's promises an unforgettable seafood journey that keeps patrons coming back for more.
A photo of Coasterra restaurant
4.7
Exceptional(7706)
Price: Moderate
• Mexican • Harbor Island
Booked 108 times today
Coasterra, nestled in the scenic Harbor Island of San Diego, is a beacon of exceptional Seafood cuisine. With breathtaking views of the bay and the city skyline, Coasterra offers an unforgettable dining experience that pairs perfectly with its high-quality Seafood offerings. Guests rave about standout dishes like the "Blood Orange Scallop Aguachile" and the "hefty and delicious" mahi tacos, both of which showcase the restaurant's dedication to authentic and flavorful Seafood. The ambiance and service complement the exquisite cuisine, making every visit a delightful occasion. Whether celebrating a special moment or enjoying a casual meal, Coasterra promises a Seafood experience that is both memorable and delectable.

How is content generated

See what locals rave about

From verified diners like you
From verified diners like you

Discover best Mexican / Southwestern restaurants in Little Italy

Discover the vibrant flavors of Mexican cuisine right in the heart of San Diego's Little Italy, a culinary hotspot known for its diverse and robust dining scene. Here, you'll find an array of Mexican restaurants that masterfully blend traditional Latin dishes with unique, local twists. Each establishment offers a distinct experience, from authentic Baja-style seafood at Crudo Ceviche & Oyster Bar to the innovative fusion of Latin and Asian flavors at King & Queen Cantina. Patrons consistently praise the high-quality food, ranging from birria tacos to exquisite ceviche, and commend the excellent service and cozy atmospheres. Whether you’re looking for a lively spot for Happy Hour or a sophisticated setting for a family meal, Little Italy’s Mexican restaurants provide exceptional dining experiences that cater to all tastes. Embrace the rich culinary traditions and modern interpretations of Mexican cuisine in one of San Diego's most charming neighborhoods.

  • Privacy policy
  • Terms of Use
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable Australia Level 22, 357 Collins Street, Melbourne, Victoria - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo